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Article

Folate status, genomic DNA hypomethylation, and risk of colorectal adenoma and cancer: a case control study.

Gastroenterology - 1 May 2003

Pufulete Maria, Al-Ghnaniem Reyad, Leather Andrew J M, Appleby Paul, Gout Sally, Terry Catherine, Emery Peter W, Sanders Thomas A B

Abstract excerpt

BACKGROUND & AIMS: Low folate intake may increase risk for colorectal cancer by inducing DNA hypomethylation. This study reports the influence of folate status, DNA methylation, and polymorphisms of methylenetetrahydrofolate reductase (MTHFR 677C-->T and 1298A-->C), methionine synthase (MS 2756A-->G), and cystathionine-beta-synthase (CBS 844ins68) on risk for developing colorectal neoplasia. METHODS: Thirty-five...

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PMID: 12730865
DOI: 10.1016/s0016-5085(03)00279-8

Genes

CBS
MTHFR

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Source receipt: pubmed, retrieved 7 Sept 2026.

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