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Article

Influence of folate status on genomic DNA methylation in colonic mucosa of subjects without colorectal adenoma or cancer.

British journal of cancer - 14 Mar 2005

Pufulete M, Al-Ghnaniem R, Rennie J A, Appleby P, Harris N, Gout S, Emery P W, Sanders T A

Abstract excerpt

DNA hypomethylation may increase the risk of colorectal cancer. The main aim of this study was to assess the influence of folate status (serum and erythrocyte folate and plasma homocysteine concentrations) on DNA methylation. Methylenetetrahydrofolate reductase (MTHFR 677C --> T and 1298A --> C), methionine synthase (MS 2756A --> G) and cystathionine synthase (CBS 844ins68) polymorphisms were measured to account...

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Share to 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 15726099
DOI: 10.1038/sj.bjc.6602439
PMCID: PMC2361912

Genes

CBS
MTHFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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