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Article

Localized depletion: the key to colorectal cancer risk mediated by MTHFR genotype and folate?

Cancer causes & control : CCC - 1 Oct 2006

Brockton N T

Abstract excerpt

Dietary folate has been consistently associated with reduced risk of colorectal cancer (CRC). One of the known biochemical roles of folate is donation of methyl moieties. DNA hypomethylation is an early and almost ubiquitous occurrence in tumor tissue. Therefore, it was originally suggested that adequate folate intake contributed to reduced risk of CRC by facilitating methyl-mediated silencing of oncogenes....

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Source

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PMID: 16933051
DOI: 10.1007/s10552-006-0051-5

Genes

MTHFR

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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