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Article

Methylenetetrahydrofolate reductase polymorphism, dietary interactions, and risk of colorectal cancer.

Cancer research - 15 Mar 1997

Ma J, Stampfer M J, Giovannucci E, Artigas C, Hunter D J, Fuchs C, Willett W C, Selhub J, Hennekens C H, Rozen R

Abstract excerpt

Folate derivatives are important in experimental colorectal carcinogenesis; low folate intake, particularly with substantial alcohol intake, is associated with increased risk. The enzyme 5,10-methylenetetrahydrofolate reductase (MTHFR) catalyzes the conversion of 5,10-methylenetetrahydrofolate, required for purine and thymidine syntheses, to 5-methyltetrahydrofolate, the primary circulatory form of folate...

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PMID: 9067278

Genes

MTHFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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