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Article

Polymorphisms in genes involved in folate metabolism and colorectal neoplasia: a HuGE review.

American journal of epidemiology - 1 Mar 2004

Sharp Linda, Little Julian

Abstract excerpt

Epidemiologic and mechanistic evidence suggests that folate is involved in colorectal neoplasia. Some polymorphic genes involved in folate metabolism--methylenetetrahydrofolate reductase (MTHFR C677T and A1298C), methionine synthase (MTR A2756G), methionine synthase reductase (MTRR A66G), cystathionine beta-synthase (CBS exon 8, 68-base-pair insertion), and thymidylate synthase (TS enhancer region and 3'...

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Topics

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Share to 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase
Share to Colorectal Neoplasms

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Ferredoxin-NADP Reductase

Share to Folic Acid

Share to Genetic Predisposition to Disease

Share to Methylenetetrahydrofolate Reductase (NADPH2)

Share to Polymorphism, Genetic

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Source

Identifiers

PMID: 14977639
DOI: 10.1093/aje/kwh066

Genes

MTHFR
CBS
MTR
MTRR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Polymorphisms in genes involved in folate metabolism and colorectal neoplasia: a HuGE review.PMID 14977639Read ↗

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