Drosophila Kdm4 demethylases in histone H3 lysine 9 demethylation and ecdysteroid signaling.

doi:10.1038/srep02894

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Article

Drosophila Kdm4 demethylases in histone H3 lysine 9 demethylation and ecdysteroid signaling.

Scientific reports - 8 Oct 2013

Tsurumi Amy, Dutta Pranabananda, Dutta Pranabanada, Shang Robin, Yan Shian-Jang, Sheng Robin, Li Willis X

Abstract excerpt

The dynamic regulation of chromatin structure by histone post-translational modification is an essential regulatory mechanism that controls global gene transcription. The Kdm4 family of H3K9me2,3 and H3K36me2,3 dual specific histone demethylases has been implicated in development and tumorigenesis. Here we show that Drosophila Kdm4A and Kdm4B are together essential for mediating ecdysteroid hormone signaling...

Topics

Animals
Animals, Genetically Modified
Drosophila
Drosophila Proteins
Ecdysteroids
Gene Knockout Techniques
Gene Order
Histone Demethylases
Histones
Homozygote
Methylation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Models, Biological

Mutation

Phenotype

Promoter Regions, Genetic

Protein Binding

Protein Transport

Receptors, Steroid

Source

Open in PubMed Open full text

Identifiers

PMID: 24100631
DOI: 10.1038/srep02894
PMCID: PMC3792421

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-24100631-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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