Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A developmental genetic analysis of the lysine demethylase KDM2 mutations in Drosophila melanogaster.

Mechanisms of development - 1 Aug 2014

Zheng Yani, Hsu Fu-Ning, Xu Wu, Xie Xiao-Jun, Ren Xinjie, Gao Xinsheng, Ni Jian-Quan, Ji Jun-Yuan

Abstract excerpt

Post-translational modification of histones plays essential roles in the transcriptional regulation of genes in eukaryotes. Methylation on basic residues of histones is regulated by histone methyltransferases and histone demethylases, and misregulation of these enzymes has been linked to a range of diseases such as cancer. Histone lysine demethylase 2 (KDM2) family proteins have been shown to either promote or...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Animals, Genetically Modified
Share to Chromosome Deletion

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Conserved Sequence

Share to DNA Transposable Elements

Share to Gene Expression Regulation, Enzymologic

Share to Gene Knockout Techniques

Share to Genes, Insect

Share to Jumonji Domain-Containing Histone Demethylases

Source

Open in PubMed Open full text

Identifiers

PMID: 25016215
DOI: 10.1016/j.mod.2014.06.003
PMCID: PMC4177295

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A developmental genetic analysis of the lysine demethylase KDM2 mutations in Drosophila melanogaster.PMID 25016215Read ↗

The lysine demethylase dKDM2 is non-essential for viability, but regulates circadian rhythms in <i>Drosophila</i>Semantic proximity Read ↗

Drosophila KDM2 is a H3K4me3 demethylase regulating nucleolar organizationSemantic proximity Read ↗

The Histone Demethylase KDM5 Is Essential for Larval Growth in Drosophila.Semantic proximity Read ↗

Gene regulation by the lysine demethylase KDM4A in Drosophila.Semantic proximity Read ↗

Drosophila Kdm4 demethylases in histone H3 lysine 9 demethylation and ecdysteroid signaling.Semantic proximity Read ↗

De novo variants in KDM2A cause a syndromic neurodevelopmental disorder.Semantic proximity Read ↗

De novo variants in<i>KDM2A</i>cause a syndromic neurodevelopmental disorderSemantic proximity Read ↗

Loss of the chromatin modifier Kdm2aa causes BrafV600E-independent spontaneous melanoma in zebrafish.Semantic proximity Read ↗

The histone lysine methyltransferase KMT2D sustains a gene expression program that represses B cell lymphoma development.Semantic proximity Read ↗

Phenotypic characterization of SETD3 knockout Drosophila.Semantic proximity Read ↗

Histone H3 lysine 4 methyltransferase KMT2D.Semantic proximity Read ↗

The histone demethylase Dmel\Kdm4A controls genes required for life span and male-specific sex determination in Drosophila.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.