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Article

Drosophila Histone Demethylase KDM4A Has Enzymatic and Non-enzymatic Roles in Controlling Heterochromatin Integrity.

Developmental cell - 24 Jul 2017

Colmenares Serafin U, Swenson Joel M, Langley Sasha A, Kennedy Cameron, Costes Sylvain V, Karpen Gary H

Abstract excerpt

Eukaryotic genomes are broadly divided between gene-rich euchromatin and the highly repetitive heterochromatin domain, which is enriched for proteins critical for genome stability and transcriptional silencing. This study shows that Drosophila KDM4A (dKDM4A), previously characterized as a euchromatic histone H3 K36 demethylase and transcriptional regulator, predominantly localizes to heterochromatin and regulates...

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Identifiers

PMID: 28743002
DOI: 10.1016/j.devcel.2017.06.014
PMCID: PMC5572651

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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