Article
Drosophila Histone Demethylase KDM4A Has Enzymatic and Non-enzymatic Roles in Controlling Heterochromatin Integrity.
Developmental cell - 24 Jul 2017
Colmenares Serafin U, Swenson Joel M, Langley Sasha A, Kennedy Cameron, Costes Sylvain V, Karpen Gary H
Abstract excerpt
Eukaryotic genomes are broadly divided between gene-rich euchromatin and the highly repetitive heterochromatin domain, which is enriched for proteins critical for genome stability and transcriptional silencing. This study shows that Drosophila KDM4A (dKDM4A), previously characterized as a euchromatic histone H3 K36 demethylase and transcriptional regulator, predominantly localizes to heterochromatin and regulates...
Topics
- Animals
- Biocatalysis
- Cell Cycle
- Cell Cycle Checkpoints
- Chromosomal Position Effects
- DNA Breaks, Double-Stranded
- DNA Repair
- Drosophila Proteins
- Drosophila melanogaster
- Fertility
- Gene Expression Regulation
- Gene Silencing
- Heterochromatin