Article
Functional antagonism between histone H3K4 demethylases in vivo.
Genes & development - 1 Jan 2011
Di Stefano Luisa, Walker James A, Burgio Giosalba, Corona Davide F V, Mulligan Peter, Näär Anders M, Dyson Nicholas J
Abstract excerpt
Dynamic regulation of histone modifications is critical during development, and aberrant activity of chromatin-modifying enzymes has been associated with diseases such as cancer. Histone demethylases have been shown to play a key role in eukaryotic gene transcription; however, little is known about how their activities are coordinated in vivo to regulate specific biological processes. In Drosophila, two enzymes,...
Topics
- Animals
- Drosophila Proteins
- Drosophila melanogaster
- Gene Expression Regulation
- Heterochromatin
- Histone Demethylases
- Histone-Lysine N-Methyltransferase
- Histones
- Methylation
- Mutation
- Oxidoreductases, N-Demethylating
- Phenotype
- Receptors, Notch