Mutation of Drosophila Lsd1 disrupts H3-K4 methylation, resulting in tissue-specific defects during development.

Abstract excerpt

Histone-tail modifications play a fundamental role in the processes that establish chromatin structure and determine gene expression. One such modification, histone methylation, was considered irreversible until the recent discovery of histone demethylases. Lsd1 was the first histone demethylase to be identified. Lsd1 is highly conserved in many species, from yeast to humans, but its function has primarily been...

Topics

• Animals
• Blotting, Western
• DNA Methylation
• Drosophila
• Drosophila Proteins
• Gene Expression Regulation, Developmental
• Histones
• Mutation
• Oxidoreductases, N-Demethylating
• Phenotype