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Article

Maternal expression of the histone demethylase Kdm4a is crucial for pre-implantation development

22 Aug 2017

Abstract excerpt

Regulation of chromatin composition through post-translational modifications of histones contributes to transcriptional regulation and is essential for many cellular processes, including differentiation and development. KDM4A (JMJD2A) is a lysine demethylase with specificity towards di- and tri-methylated lysine 9 and lysine 36 of histone H3 (H3K9me2/me3 and H3K36me2/me3). Here, we report that Kdm4a as a maternal...

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PMID: 28827393
DOI: 10.1242/dev.155473

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