Article
EYA4 is inactivated biallelically at a high frequency in sporadic lung cancer and is associated with familial lung cancer risk.
Oncogene - 4 Sept 2014
Wilson I M, Vucic E A, Enfield K S S, Thu K L, Zhang Y A, Chari R, Lockwood W W, Radulovich N, Starczynowski D T, Banáth J P, Zhang M, Pusic A, Fuller M, Lonergan K M, Rowbotham D, Yee J, English J C, Buys T P H, Selamat S A, Laird-Offringa I A, Liu P, Anderson M, You M, Tsao M S, Brown C J, Bennewith K L, MacAulay C E, Karsan A, Gazdar A F, Lam S, Lam W L
Abstract excerpt
In an effort to identify novel biallelically inactivated tumor suppressor genes (TSGs) in sporadic invasive and preinvasive non-small-cell lung cancer (NSCLC) genomes, we applied a comprehensive integrated multiple 'omics' approach to investigate patient-matched, paired NSCLC tumor and non-malignant parenchymal tissues. By surveying lung tumor genomes for genes concomitantly inactivated within individual tumors...
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