Article
Pan-cancer analysis of biallelic inactivation in tumor suppressor genes identifies KEAP1 zygosity as a predictive biomarker in lung cancer.
Cell - 6 Feb 2025
Zucker Mark, Perry Maria A, Gould Samuel I, Elkrief Arielle, Safonov Anton, Thummalapalli Rohit, Mehine Miika, Chakravarty Debyani, Brannon A Rose, Ladanyi Marc, Razavi Pedram, Donoghue Mark T A, Murciano-Goroff Yonina R, Grigoriadis Kristiana, McGranahan Nicholas, Jamal-Hanjani Mariam, Swanton Charles, Chen Yuan, Shen Ronglai, Chandarlapaty Sarat, Solit David B, Schultz Nikolaus, Berger Michael F, Chang Jason, Schoenfeld Adam J, Sánchez-Rivera Francisco J, Reznik Ed, Bandlamudi Chaitanya
Abstract excerpt
The canonical model of tumor suppressor gene (TSG)-mediated oncogenesis posits that loss of both alleles is necessary for inactivation. Here, through allele-specific analysis of sequencing data from 48,179 cancer patients, we define the prevalence, selective pressure for, and functional consequences of biallelic inactivation across TSGs. TSGs largely assort into distinct classes associated with either pan-cancer...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.