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Article

Genomic Landscape Established by Allelic Imbalance in the Cancerization Field of a Normal Appearing Airway

24 May 2016

Abstract excerpt

Visually normal cells adjacent to, and extending from, tumors of the lung may carry molecular alterations characteristics of the tumor itself, an effect referred to as airway field of cancerization. This airway field has been postulated as a model for early events in lung cancer pathogenesis. Yet the genomic landscape of somatically acquired molecular alterations in airway epithelia of lung cancer patients has...

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PMID: 27216194
DOI: 10.1158/0008-5472.can-15-3064

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