Mechanism of ERBB2 gene overexpression by the formation of super-enhancer with genomic structural abnormalities in lung adenocarcinoma without clinically actionable genetic alterations.

doi:10.1186/s12943-024-02035-6

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Article

Mechanism of ERBB2 gene overexpression by the formation of super-enhancer with genomic structural abnormalities in lung adenocarcinoma without clinically actionable genetic alterations.

Molecular cancer - 11 Jun 2024

Kaneko Syuzo, Takasawa Ken, Asada Ken, Shiraishi Kouya, Ikawa Noriko, Machino Hidenori, Shinkai Norio, Matsuda Maiko, Masuda Mari, Adachi Shungo, Takahashi Satoshi, Kobayashi Kazuma, Kouno Nobuji, Bolatkan Amina, Komatsu Masaaki, Yamada Masayoshi, Miyake Mototaka, Watanabe Hirokazu, Tateishi Akiko, Mizuno Takaaki, Okubo Yu, Mukai Masami, Yoshida Tatsuya, Yoshida Yukihiro, Horinouchi Hidehito, Watanabe Shun-Ichi, Ohe Yuichiro, Yatabe Yasushi, Saloura Vassiliki, Kohno Takashi, Hamamoto Ryuji

Abstract excerpt

BACKGROUND: In an extensive genomic analysis of lung adenocarcinomas (LUADs), driver mutations have been recognized as potential targets for molecular therapy. However, there remain cases where target genes are not identified. Super-enhancers and structural variants are frequently identified in several hundred loci per case. Despite this, most cancer research has approached the analysis of these data sets...

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Identifiers

PMID: 38862995
DOI: 10.1186/s12943-024-02035-6
PMCID: PMC11165761

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