Article

Germline determinants of risk and molecular subtype in young-onset lung cancer

2026-07-10

Abstract excerpt

<h4> A bstract </h4> Young-onset lung cancer is enriched for never-smoking and oncogene-driven tumors, yet its inherited genetic basis remains poorly defined. We performed germline whole-genome sequencing in 251 young-onset lung cancer cases (median age 37), which we jointly analyzed with never-smoking cases (n=196; median age 68) and cancer-free controls (n=1,883). We identified enrichments of rare deleterious...

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Literature Corpus work: 9a76994f-be6a-5b6a-904f-cbb50b2c6317
DOI: 10.64898/2026.06.30.26356693

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