Article
Whole Exome Sequencing of Highly Aggregated Lung Cancer Families Reveals Linked Loci for Increased Cancer Risk on Chromosomes 12q, 7p, and 4q.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Feb 2020
Musolf Anthony M, Moiz Bilal A, Sun Haiming, Pikielny Claudio W, Bossé Yohan, Mandal Diptasri, de Andrade Mariza, Gaba Colette, Yang Ping, Li Yafang, You Ming, Govindan Ramaswamy, Wilson Richard K, Kupert Elena Y, Anderson Marshall W, Schwartz Ann G, Pinney Susan M, Amos Christopher I, Bailey-Wilson Joan E
Abstract excerpt
BACKGROUND: Lung cancer kills more people than any other cancer in the United States. In addition to environmental factors, lung cancer has genetic risk factors as well, though the genetic etiology is still not well understood. We have performed whole exome sequencing on 262 individuals from 28 extended families with a family history of lung cancer. METHODS: Parametric genetic linkage analysis was performed on...
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