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Article

Contribution of genetic and epigenetic mechanisms to Wnt pathway activity in prevalent skeletal disorders.

Gene - 15 Dec 2013

García-Ibarbia Carmen, Delgado-Calle Jesús, Casafont Iñigo, Velasco Javier, Arozamena Jana, Pérez-Núñez María I, Alonso María A, Berciano María T, Ortiz Fernando, Pérez-Castrillón José L, Fernández Agustín F, Fraga Mario F, Zarrabeitia María T, Riancho José A

Abstract excerpt

We reported previously that the expression of Wnt-related genes is lower in osteoporotic hip fractures than in osteoarthritis. We aimed to confirm those results by analyzing β-catenin levels and explored potential genetic and epigenetic mechanisms involved. β-Catenin gene expression and nuclear levels were analyzed by real time PCR and confocal immunofluorescence. Increased nuclear β-catenin was found in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 24096177
DOI: 10.1016/j.gene.2013.09.080

Genes

FZD10
SFRP1
SFRP4
WNT16
WNT4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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