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Article

Low osteocalcin/collagen type I bone gene expression ratio is associated with hip fragility fractures.

Bone - 1 Dec 2012

Rodrigues Ana M, Caetano-Lopes Joana, Vale Ana C, Vidal Bruno, Lopes Ana, Aleixo Inês, Polido-Pereira Joaquim, Sepriano Alexandre, Perpétuo Inês P, Monteiro Jacinto, Vaz Maria F, Fonseca João E, Canhão Helena

Abstract excerpt

INTRODUCTION: Osteocalcin (OC) is the most abundant non-collagenous bone protein and is determinant for bone mineralization. We aimed to compare OC bone expression and serum factors related to its carboxylation in hip fragility fracture and osteoarthritis patients. We also aimed to identify which of these factors were associated with worse mechanical behavior and with the hip fracture event. METHODS: In this...

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PMID: 22975110
DOI: 10.1016/j.bone.2012.08.129

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