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Genome‐wide profiling of bone reveals differentially methylated regions in osteoporosis and osteoarthritis

2 Nov 2012

Abstract excerpt

OBJECTIVE: To determine genome-wide methylation profiles of bone from patients with hip osteoarthritis (OA) and those with osteoporotic (OP) hip fractures. METHODS: Trabecular bone pieces were obtained from the central part of the femoral head of 27 patients with hip fractures and 26 patients with hip OA. DNA was isolated, and methylation was explored with Illumina methylation arrays. RNA was extracted, pooled,...

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PMID: 23124911
DOI: 10.1002/art.37753

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