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Article

Functional and association analysis of frizzled 1 (FZD1) promoter haplotypes with femoral neck geometry.

Bone - 1 Apr 2010

Zhang Yingze, Kuipers Allison L, Yerges-Armstrong Laura M, Nestlerode Cara S, Jin Zhao, Wheeler Victor W, Patrick Alan L, Bunker Clareann H, Zmuda Joseph M

Abstract excerpt

Frizzleds are receptors for Wnt signaling and are involved in skeletal morphogenesis. Little is known about the transcriptional regulation of frizzleds in bone cells. In the current study, we determined if two common and potentially functional genetic variants (rs2232157, rs2232158) in the frizzled-1 (FZD1) promoter region and their haplotypes influence FZD1 promoter activity in human osteoblast-like cells. We...

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Source

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Identifiers

PMID: 20051274
DOI: 10.1016/j.bone.2009.12.026
PMCID: PMC2842476

Genes

FZD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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