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Article

Evidence for a differential association of the Arg200Trp single-nucleotide polymorphism in FRZB with hip osteoarthritis and osteoporosis

15 Nov 2005

Abstract excerpt

Sir, Osteoarthritis and osteoporosis are disabling diseases in the elderly. Clinical observations suggest an inverse relationship between these disorders (for review see [1]). This hypothesis is still controversial and no molecular basis for this observation has been demonstrated. Genome-wide linkage analysis and subsequent association study identified a single-nucleotide polymorphism (SNP) (Arg324Gly) in the...

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PMID: 16287928
DOI: 10.1093/rheumatology/kei148

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