Article
Polymorphisms of the WNT10B gene, bone mineral density, and fractures in postmenopausal women.
Calcified tissue international - 1 Aug 2009
Perez-Castrillon Jose L, Olmos Jose M, Nan Daniel N, Castillo Jesus, Arozamena Jana, Montero Antonio, Perez-Nuñez María I, Riancho Jose A
Abstract excerpt
Wnt ligands are important regulators of skeletal homeostasis. Wnt10B tends to stimulate the differentiation of common mesenchymal precursors toward the osteoblastic lineage, while inhibiting adipocytic differentiation. Hence, we decided to explore the association of WNT10B allelic variants with bone mineral density and osteoporotic fractures. A set of tag SNPs capturing most common variations of the WNT10B gene...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.
