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Article

Is activation of the intra-S checkpoint in human fibroblasts an important factor in protection against UV-induced mutagenesis?

Cell cycle (Georgetown, Tex.) - 15 Nov 2013

Sproul Christopher D, Rao Shangbang, Ibrahim Joseph G, Kaufmann William K, Cordeiro-Stone Marila

Abstract excerpt

The ATR/CHK1-dependent intra-S checkpoint inhibits replicon initiation and replication fork progression in response to DNA damage caused by UV (UV) radiation. It has been proposed that this signaling cascade protects against UV-induced mutations by reducing the probability that damaged DNA will be replicated before it can be repaired. Normal human fibroblasts (NHF) were depleted of ATR or CHK1, or treated with...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24091629
DOI: 10.4161/cc.26590
PMCID: PMC3906341

Genes

ATR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Is activation of the intra-S checkpoint in human fibroblasts an important factor in protection against UV-induced mutagenesis?PMID 24091629Read ↗

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