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Article

ATR kinase is required for global genomic nucleotide excision repair exclusively during S phase in human cells

11 Nov 2008

Abstract excerpt

Global-genomic nucleotide excision repair (GG-NER) is the only pathway available to humans for removal, from the genome overall, of highly genotoxic helix-distorting DNA adducts generated by many environmental mutagens and certain chemotherapeutic agents, e.g., UV-induced 6-4 photoproducts (6-4PPs) and cyclobutane pyrimidine dimers (CPDs). The ataxia telangiectasia and rad-3-related kinase (ATR) is rapidly...

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PMID: 19004803
DOI: 10.1073/pnas.0801585105

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