Article
hRev7, putative subunit of hPolzeta, plays a critical role in survival, induction of mutations, and progression through S-phase, of UV((254nm))-irradiated human fibroblasts.
DNA repair - 2 Apr 2008
McNally Kristin, Neal Jessica A, McManus Terrence P, McCormick J Justin, Maher Veronica M
Abstract excerpt
Translesion synthesis (TLS) refers to mechanisms by which specialized DNA polymerases incorporate nucleotides opposite fork-blocking lesions and extend replication until standard replicative polymerases take over. The first eukaryotic TLS polymerase discovered, S. cerevisiae Polzeta, consists of catalytic subunit Rev3 and non-catalytic subunit Rev7. Human homologs of these two proteins have been identified....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.