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Article

Association of deficient DNA repair during G2 phase with progression from benign to malignant state in a line of human skin keratinocytes transfected with ras oncogene.

Carcinogenesis - 1 Jan 1994

Parshad R, Sanford K K, Price F M, Rhim J S, Tarone R E, Fusenig N E, Boukamp P

Abstract excerpt

Human skin keratinocytes after malignant neoplastic transformation by infection with Kirsten murine sarcoma virus (KiMSV) or transfection with pSV2 ras (containing an activated c-Ha-ras oncogene) showed a DNA repair deficiency(ies). The repair deficiency was manifest as an abnormally high frequency of chromatid breaks and gaps persisting after X-ray-induced DNA damage inflicted during the G2 phase of the cell...

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Identifiers

PMID: 8293545
DOI: 10.1093/carcin/15.1.33

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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