Association of deficient DNA repair during G2 phase with progression from benign to malignant state in a line of human skin keratinocytes transfected with ras oncogene.

doi:10.1093/carcin/15.1.33

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Article

Association of deficient DNA repair during G2 phase with progression from benign to malignant state in a line of human skin keratinocytes transfected with ras oncogene.

Carcinogenesis - 1 Jan 1994

Parshad R, Sanford K K, Price F M, Rhim J S, Tarone R E, Fusenig N E, Boukamp P

Abstract excerpt

Human skin keratinocytes after malignant neoplastic transformation by infection with Kirsten murine sarcoma virus (KiMSV) or transfection with pSV2 ras (containing an activated c-Ha-ras oncogene) showed a DNA repair deficiency(ies). The repair deficiency was manifest as an abnormally high frequen...

Topics

Animals
Cell Transformation, Neoplastic
Chromatids
DNA Repair
DNA, Neoplasm
G2 Phase
Gene Expression
Genes, ras
Humans
Keratinocytes
Male
Mice

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice, Nude

Neoplasms, Radiation-Induced

Phenotype

Skin

Skin Neoplasms

Skin Physiological Phenomena

Source

Open in PubMed

Identifiers

PMID: 8293545
DOI: 10.1093/carcin/15.1.33

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8293545-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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