Article

A local ATR-dependent checkpoint pathway is activated by a site-specific replication fork block in human cells

2023-03-26

Abstract excerpt

When replication forks encounter DNA lesions that cause polymerase stalling a checkpoint pathway is activated. The ATR-dependent intra-S checkpoint pathway mediates detection and processing of sites of replication fork stalling to maintain genomic integrity. Several factors involved in the global checkpoint pathway have been identified, but the response to a single replication fork barrier (RFB) is poorly understo...

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Literature Corpus work: a0396008-3985-5a31-96c7-8f6b6f3d2275
DOI: 10.1101/2023.03.26.534293

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