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Article

ATR enforces the topoisomerase II-dependent G2 checkpoint through inhibition of Plk1 kinase.

The Journal of biological chemistry - 27 Sept 2002

Deming Paula B, Flores Kristina G, Downes C Stephen, Paules Richard S, Kaufmann William K

Abstract excerpt

An ATR-dependent G(2) checkpoint responds to inhibition of topoisomerase II and delays entry into mitosis by sustaining nuclear exclusion of cyclin B1-Cdk1 complexes. Here we report that induction of this checkpoint with ICRF-193, a topoisomerase II catalytic inhibitor that does not cause DNA damage, was associated with an ATR-dependent inhibition of polo-like kinase 1 (Plk1) kinase activity and a decrease in...

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Identifiers

PMID: 12147700
DOI: 10.1074/jbc.M206109200

Genes

ATR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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