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Article

An ATR- and Chk1-dependent S checkpoint inhibits replicon initiation following UVC-induced DNA damage.

Molecular and cellular biology - 1 Dec 2002

Heffernan Timothy P, Simpson Dennis A, Frank Alexandra R, Heinloth Alexandra N, Paules Richard S, Cordeiro-Stone Marila, Kaufmann William K

Abstract excerpt

Inhibition of replicon initiation is a stereotypic DNA damage response mediated through S checkpoint mechanisms not yet fully understood. Studies were undertaken to elucidate the function of checkpoint proteins in the inhibition of replicon initiation following irradiation with 254 nm UV light (UVC) of diploid human fibroblasts immortalized by the ectopic expression of telomerase. Velocity sedimentation analysis...

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Source

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Identifiers

PMID: 12446774
DOI: 10.1128/MCB.22.24.8552-8561.2002
PMCID: PMC139882

Genes

ATR
ATM
UCN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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An ATR- and Chk1-dependent S checkpoint inhibits replicon initiation following UVC-induced DNA damage.PMID 12446774Read ↗

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