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Article

DNA damage-induced accumulation of centrosomal Chk1 contributes to its checkpoint function.

Cell cycle (Georgetown, Tex.) - 15 Oct 2007

Löffler Harald, Bochtler Tilmann, Fritz Britta, Tews Björn, Ho Anthony D, Lukas Jiri, Bartek Jiri, Krämer Alwin

Abstract excerpt

The checkpoint kinase Chk1 is an established transducer of ATR- and ATM-dependent signalling in response to DNA damage. In addition to its nuclear localization, Chk1 localizes to interphase centrosomes and thereby negatively regulates entry into mitosis by preventing premature activation of cyclin B-Cdk1 during unperturbed cell cycles. Here, we demonstrate that DNA damage caused by ultraviolet irradiation or...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17726372
DOI: 10.4161/cc.6.20.4810

Genes

ATM
ATR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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