Activation of polyamine catabolism profoundly alters tissue polyamine pools and affects hair growth and female fertility in transgenic mice overexpressing spermidine/spermine N1-acetyltransferase.

doi:10.1074/jbc.272.30.18746

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Article

Activation of polyamine catabolism profoundly alters tissue polyamine pools and affects hair growth and female fertility in transgenic mice overexpressing spermidine/spermine N1-acetyltransferase.

The Journal of biological chemistry - 25 Jul 1997

Pietilä M, Alhonen L, Halmekytö M, Kanter P, Jänne J, Porter C W

Abstract excerpt

We have generated a transgenic mouse line that overexpresses the rate-controlling enzyme of polyamine catabolism, spermidine/spermine N1-acetyltransferase. Tissues of these mice showed markedly distorted polyamine pools, which in most cases were characterized by the appearance of N1-acetylspermid...

Topics

Acetyltransferases
Animals
Blotting, Northern
Cell Differentiation
Epidermal Cells
Female
Gene Dosage
Gene Expression
Hair
Infertility, Female
Mice
Mice, Inbred BALB C

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice, Inbred DBA

Mice, Transgenic

Phenotype

Polyamines

Putrescine

RNA, Messenger

Source

Open in PubMed

Identifiers

PMID: 9228047
DOI: 10.1074/jbc.272.30.18746

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9228047-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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