Article
Relation of skin polyamines to the hairless phenotype in transgenic mice overexpressing spermidine/spermine N-acetyltransferase.
The Journal of investigative dermatology - 1 May 2001
Pietilä M, Parkkinen J J, Alhonen L, Jänne J
Abstract excerpt
We recently generated a transgenic mouse line with activated polyamine catabolism due to overexpression of spermidine/spermine N1-acetyltransferase. Phenotypic changes in these animals included permanent loss of hair at the age of 3 wk. We have now further explored development of hair loss during early postnatal life. The first hair cycle appeared to be completed normally in the transgenic animals. At postnatal...
Topics
- 9,10-Dimethyl-1,2-benzanthracene
- Acetyltransferases
- Aging
- Alopecia
- Animals
- Animals, Newborn
- Carcinogens
- Mice
- Mice, Transgenic
- Neoplasm Staging
- Ornithine Decarboxylase
- Papilloma
- Phenotype
- Polyamines
- Putrescine