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Hairless Suppresses Vitamin D Receptor Transactivation in Human Keratinocytes

4 Nov 2005

Abstract excerpt

The vitamin D receptor (VDR) and its ligand 1,25-dihydroxyvitamin D3 [1,25(OH)2D3] are required for normal keratinocyte differentiation. Both the epidermis and the hair follicle are disrupted in VDR-null mice. Hairless (Hr), a presumptive transcription factor with no known ligand, when mutated, disrupts hair follicle cycling similar to the effects of VDR mutations. Hr, like VDR, is found in the nuclei of...

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Identifiers

PMID: 16269453
DOI: 10.1210/en.2005-1111

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Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Hairless Suppresses Vitamin D Receptor Transactivation in Human KeratinocytesPMID 16269453Read ↗

Physical and functional interaction between the vitamin D receptor and hairless corepressor, two proteins required for hair cycling.Semantic proximity Read ↗

Analysis of hairless corepressor mutants to characterize molecular cooperation with the vitamin D receptor in promoting the mammalian hair cycle.Semantic proximity Read ↗

The co-repressor hairless has a role in epithelial cell differentiation in the skin.Semantic proximity Read ↗

Development and progression of alopecia in the vitamin D receptor null mouseSemantic proximity Read ↗

Interactions of the Vitamin D Receptor with the Corepressor HairlessSemantic proximity Read ↗

Ligand-independent actions of the vitamin D receptor maintain hair follicle homeostasis.Semantic proximity Read ↗

Atrichia caused by mutations in the vitamin D receptor gene is a phenocopy of generalized atrichia caused by mutations in the hairless gene.Semantic proximity Read ↗

Molecular and functional aspects of the hairless (hr) gene in laboratory rodents and humans.Semantic proximity Read ↗

Targeting Expression of the Human Vitamin D Receptor to the Keratinocytes of Vitamin D Receptor Null Mice Prevents AlopeciaSemantic proximity Read ↗

Hairless and NFκB form a positive feedback loop after UVB and TNFα stimulation.Semantic proximity Read ↗

The hairless gene mutated in congenital hair loss disorders encodes a novel nuclear receptor corepressor.Semantic proximity Read ↗

Hairless is a histone H3K9 demethylase.Semantic proximity Read ↗

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