Article
The hairless gene mutated in congenital hair loss disorders encodes a novel nuclear receptor corepressor.
Genes & development - 15 Oct 2001
Potter G B, Beaudoin G M, DeRenzo C L, Zarach J M, Chen S H, Thompson C C
Abstract excerpt
The mammalian hairless (hr) gene plays a critical role in the maintenance of hair growth. Although the hr gene has been identified, the biochemical function of its encoded protein (Hr) has remained obscure. Here, we show that Hr functions as a transcriptional corepressor for thyroid hormone receptors (TRs). We find that two independent regions of Hr mediate TR binding and that interaction requires a cluster of...
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