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Article

Analysis of hairless corepressor mutants to characterize molecular cooperation with the vitamin D receptor in promoting the mammalian hair cycle.

Journal of cellular biochemistry - 1 Jun 2010

Hsieh Jui-Cheng, Slater Stephanie A, Whitfield G Kerr, Dawson Jamie L, Hsieh Grace, Sheedy Craig, Haussler Carol A, Haussler Mark R

Abstract excerpt

The mammalian hair cycle requires both the vitamin D receptor (VDR) and the hairless (Hr) corepressor, each of which is expressed in the hair follicle. Hr interacts directly with VDR to repress VDR-targeted transcription. Herein, we further map the VDR-interaction domain to regions in the C-terminal half of Hr that contain two LXXLL-like pairs of motifs known to mediate contact of Hr with the RAR-related orphan...

Topics

Alopecia
Animals
Conserved Sequence
Hair
Histone Deacetylases
Humans
Immunoprecipitation
Mutagenesis, Site-Directed
Mutation
Rats
Receptors, Calcitriol

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 20512927
DOI: 10.1002/jcb.22578
PMCID: PMC2879709

Genes

VDR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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Analysis of hairless corepressor mutants to characterize molecular cooperation with the vitamin D receptor in promoting the mammalian hair cycle.PMID 20512927Read ↗

Interactions of the Vitamin D Receptor with the Corepressor HairlessSemantic proximity Read ↗

Physical and functional interaction between the vitamin D receptor and hairless corepressor, two proteins required for hair cycling.Semantic proximity Read ↗

The hairless gene mutated in congenital hair loss disorders encodes a novel nuclear receptor corepressor.Semantic proximity Read ↗

Hairless Suppresses Vitamin D Receptor Transactivation in Human KeratinocytesSemantic proximity Read ↗

A novel missense mutation in the mouse hairless gene causes irreversible hair loss: genetic and molecular analyses of Hr m1Enu.Semantic proximity Read ↗

Ligand-independent actions of the vitamin D receptor maintain hair follicle homeostasis.Semantic proximity Read ↗

Molecular and functional aspects of the hairless (hr) gene in laboratory rodents and humans.Semantic proximity Read ↗

Hairless is a histone H3K9 demethylase.Semantic proximity Read ↗

Molecular basis for hair loss in mice carrying a novel nonsense mutation (Hrrh-R ) in the hairless gene (Hr).Semantic proximity Read ↗

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The "bald Mill Hill" mutation in the mouse is associated with an abnormal, mislocalized HR bmh protein.Semantic proximity Read ↗

A novel mutation in helix 12 of the vitamin D receptor impairs coactivator interaction and causes hereditary 1,25-dihydroxyvitamin D-resistant rickets without alopecia.Semantic proximity Read ↗

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