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Interactions of the Vitamin D Receptor with the Corepressor Hairless

4 Jul 2007

Abstract excerpt

Atrichia with papular lesions (APL) and hereditary vitamin D-resistant rickets have a similar congenital hair loss disorder caused by mutations in hairless (HR) and vitamin D receptor (VDR) genes, respectively. HR is a VDR corepressor, and it has been hypothesized that VDR.HR suppress gene expression during specific phases of the hair cycle. In this study, we examined the corepressor activity of HR mutants...

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PMID: 17609203
DOI: 10.1074/jbc.m702939200

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Interactions of the Vitamin D Receptor with the Corepressor HairlessPMID 17609203Read ↗

Analysis of hairless corepressor mutants to characterize molecular cooperation with the vitamin D receptor in promoting the mammalian hair cycle.Semantic proximity Read ↗

The hairless gene mutated in congenital hair loss disorders encodes a novel nuclear receptor corepressor.Semantic proximity Read ↗

Physical and functional interaction between the vitamin D receptor and hairless corepressor, two proteins required for hair cycling.Semantic proximity Read ↗

Clinical and pathologic correlations in genetically distinct forms of atrichia.Semantic proximity Read ↗

Atrichia caused by mutations in the vitamin D receptor gene is a phenocopy of generalized atrichia caused by mutations in the hairless gene.Semantic proximity Read ↗

Hairless Suppresses Vitamin D Receptor Transactivation in Human KeratinocytesSemantic proximity Read ↗

Hairless is a histone H3K9 demethylase.Semantic proximity Read ↗

Identification of mutations in the human hairless gene in two new families with congenital atrichia.Semantic proximity Read ↗

Ligand-independent actions of the vitamin D receptor maintain hair follicle homeostasis.Semantic proximity Read ↗

The co-repressor hairless has a role in epithelial cell differentiation in the skin.Semantic proximity Read ↗

Identification of a novel splice site mutation in the human hairless gene underlying atrichia with papular lesions.Semantic proximity Read ↗

Hairless and the polyamine putrescine form a negative regulatory loop in the epidermis.Semantic proximity Read ↗

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