A novel missense mutation in the mouse hairless gene causes irreversible hair loss: genetic and molecular analyses of Hr m1Enu.

doi:10.1016/j.ygeno.2005.12.005

Article

A novel missense mutation in the mouse hairless gene causes irreversible hair loss: genetic and molecular analyses of Hr m1Enu.

Genomics - 1 Apr 2006

Nam YoonYi, Kim Jeong Ki, Cha Dal-Sun, Cho Jae-Woo, Cho Kyu-Hyuk, Yoon SeokJoo, Yoon Jong-Bok, Oh Yang-Seok, Suh Jun-Gyo, Han Sang-Seop, Song Chang-Woo, Yoon SungJoo Kim

Abstract excerpt

A novel autosomal recessive mutant was produced using N-ethyl-N-nitrosourea mutagenesis. The characteristics of the mutant mice included progressive irreversible hair loss within a month of birth, wrinkled skin, and long curved nails. Linkage analysis revealed that the causative gene is linked to D14Mit193 on chromosome 14. Sequence analysis of the complete cDNA of the candidate gene, hairless (Hr), identified a...

Topics

Alleles
Alopecia
Amino Acid Sequence
Animals
Blotting, Western
Chromosome Mapping
Chromosomes, Mammalian
Conserved Sequence
Crosses, Genetic
DNA Mutational Analysis

DNA, Complementary

Ethylnitrosourea

Genes, Recessive

Genetic Linkage

Haplotypes

Homozygote

Mice

Mice, Inbred C57BL

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.