Article
The co-repressor hairless has a role in epithelial cell differentiation in the skin.
Development (Cambridge, England) - 1 Sept 2004
Zarach Joanna M, Beaudoin Gerard M J, Coulombe Pierre A, Thompson Catherine C
Abstract excerpt
Although mutations in the mammalian hairless (Hr) gene result in congenital hair loss disorders in both mice and humans, the precise role of Hr in skin biology remains unknown. We have shown that the protein encoded by Hr (HR) functions as a nuclear receptor co-repressor. To address the role of HR in vivo, we generated a loss-of-function (Hr-/-) mouse model. The Hr-/- phenotype includes both hair loss and severe...
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