Article
Delta-like ligand 4 regulates vascular endothelial growth factor receptor 2-driven luteal angiogenesis through induction of a tip/stalk phenotype in proliferating endothelial cells.
Fertility and sterility - 1 Dec 2013
García-Pascual Carmen M, Zimmermann Ralf C, Ferrero Hortensia, Shawber Carrie J, Kitajewski Jan, Simón Carlos, Pellicer Antonio, Gómez Raúl
Abstract excerpt
OBJECTIVE: To explore whether the Dll4/Notch-1 signaling pathway modulates vascular endothelial growth factor (VEGF)-dependent luteal angiogenesis and related function, by inducing a tip/stalk phenotype in endothelial cells (ECs). DESIGN: Experimental laboratory animal study. SETTING: University-affiliated infertility center. ANIMAL(S): Immature female mice. INTERVENTION(S): The presence of leading tip ECs in...
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