Article
TNF primes endothelial cells for angiogenic sprouting by inducing a tip cell phenotype.
Blood - 15 May 2008
Sainson Richard C A, Johnston Douglas A, Chu Henry C, Holderfield Matthew T, Nakatsu Martin N, Crampton Steven P, Davis Jaeger, Conn Erin, Hughes Christopher C W
Abstract excerpt
Pathological angiogenesis associated with wound healing often occurs subsequent to an inflammatory response that includes the secretion of cytokines such as tumor necrosis factor (TNF). Controversy exists on the angiogenic actions of TNF, with it being generally proangiogenic in vivo, but antiangiogenic in vitro. We find that whereas continuous administration of TNF in vitro or in vivo inhibits angiogenic...
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