Article
Overexpression of delta-like 4 induces arterialization and attenuates vessel formation in developing mouse embryos.
Blood - 1 Sept 2008
Trindade Alexandre, Kumar S Ram, Scehnet Jeffrey S, Lopes-da-Costa Luis, Becker Jorg, Jiang Weidong, Liu Ren, Gill Parkash S, Duarte Antonio
Abstract excerpt
The importance of Notch signaling pathway in the regulation of vascular development and angiogenesis is suggested by the expression of Notch receptors and ligands in vascular endothelial cells (ECs) and the observed vascular phenotypes in mutants of Notch receptors or ligands, especially Dll4. DLL4 is specifically expressed in arterial ECs during development, and haplo-insufficiency is embryonically lethal in...
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