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Article

The notch ligands Dll4 and Jagged1 have opposing effects on angiogenesis.

Cell - 12 Jun 2009

Benedito Rui, Roca Cristina, Sörensen Inga, Adams Susanne, Gossler Achim, Fruttiger Marcus, Adams Ralf H

Abstract excerpt

The Notch pathway is a highly conserved signaling system that controls a diversity of growth, differentiation, and patterning processes. In growing blood vessels, sprouting of endothelial tip cells is inhibited by Notch signaling, which is activated by binding of the Notch receptor to its ligand Delta-like 4 (Dll4). Here, we show that the Notch ligand Jagged1 is a potent proangiogenic regulator in mice that...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Endothelium, Vascular

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Source

Identifiers

PMID: 19524514
DOI: 10.1016/j.cell.2009.03.025

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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