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Article

Stalk cell phenotype depends on integration of Notch and Smad1/5 signaling cascades.

Developmental cell - 13 Mar 2012

Moya Iván M, Umans Lieve, Maas Elke, Pereira Paulo N G, Beets Karen, Francis Annick, Sents Ward, Robertson Elizabeth J, Mummery Christine L, Huylebroeck Danny, Zwijsen An

Abstract excerpt

Gradients of vascular endothelial growth factor (VEGF) induce single endothelial cells to become leading tip cells of emerging angiogenic sprouts. Tip cells then suppress tip-cell features in adjacent stalk cells via Dll4/Notch-mediated lateral inhibition. We report here that Smad1/Smad5-mediated BMP signaling synergizes with Notch signaling during selection of tip and stalk cells. Endothelium-specific...

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Identifiers

PMID: 22364862
DOI: 10.1016/j.devcel.2012.01.007
PMCID: PMC4544746

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