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Therapeutic advances in neural regeneration for Huntington's disease

14 Dec 2023

Abstract excerpt

Huntington's disease is a neurodegenerative disease caused by the expansion mutation of a cytosine-adenine-guanine triplet in the exon 1 of the HTT gene which is responsible for the production of the huntingtin (Htt) protein. In physiological conditions, Htt is involved in many cellular processes such as cell signaling, transcriptional regulation, energy metabolism regulation, DNA maintenance, axonal trafficking,...

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PMID: 38227527
DOI: 10.4103/1673-5374.390969

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