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Expression of brain-derived neurotrophic factor in astrocytes - Beneficial effects of glatiramer acetate in the R6/2 and YAC128 mouse models of Huntington's disease.

Experimental neurology - 1 Nov 2016

Reick Christiane, Ellrichmann Gisa, Tsai Teresa, Lee De-Hyung, Wiese Stefan, Gold Ralf, Saft Carsten, Linker Ralf A

Abstract excerpt

Glatiramer acetate (GA) is a FDA-approved drug which is licensed for the treatment of relapsing-remitting multiple sclerosis and which may exert neuroprotective effects via brain-derived neurotrophic factor (BDNF). In this study, we investigate effects of GA on BDNF expression especially in astrocytes in vitro and in vivo in brains of R6/2 and YAC128 transgenic mouse models of Huntington's disease (HD) where a...

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Identifiers

PMID: 27587303
DOI: 10.1016/j.expneurol.2016.08.012

Genes

BDNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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