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Article

A small molecule p75NTR ligand normalizes signalling and reduces Huntington's disease phenotypes in R6/2 and BACHD mice.

Human molecular genetics - 15 Nov 2016

Simmons Danielle A, Belichenko Nadia P, Ford Ellen C, Semaan Sarah, Monbureau Marie, Aiyaswamy Sruti, Holman Cameron M, Condon Christina, Shamloo Mehrdad, Massa Stephen M, Longo Frank M

Abstract excerpt

Decreases in the ratio of neurotrophic versus neurodegenerative signalling play a critical role in Huntington’s disease (HD) pathogenesis and recent evidence suggests that the p75 neurotrophin receptor (NTR) contributes significantly to disease progression. p75NTR signalling intermediates substantially overlap with those promoting neuronal survival and synapse integrity and with those affected by the mutant...

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Identifiers

PMID: 28171570
DOI: 10.1093/hmg/ddw316
PMCID: PMC5418739

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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