Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Early defect of transforming growth factor β1 formation in Huntington's disease.

Journal of cellular and molecular medicine - 1 Mar 2011

Battaglia Giuseppe, Cannella Milena, Riozzi Barbara, Orobello Sara, Maat-Schieman Marion L, Aronica Eleonora, Busceti Carla Letizia, Ciarmiello Andrea, Alberti Silvia, Amico Enrico, Sassone Jenny, Sipione Simonetta, Bruno Valeria, Frati Luigi, Nicoletti Ferdinando, Squitieri Ferdinando

Abstract excerpt

A defective expression or activity of neurotrophic factors, such as brain- and glial-derived neurotrophic factors, contributes to neuronal damage in Huntington's disease (HD). Here, we focused on transforming growth factor-β (TGF-β(1) ), a pleiotropic cytokine with an established role in mechanis...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Astrocytes
Share to Bridged Bicyclo Compounds, Heterocyclic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Huntingtin Protein

Share to Huntington Disease

Share to Positron-Emission Tomography

Share to Postmortem Changes

Share to Receptors, Metabotropic Glutamate

Share to Transforming Growth Factor beta1

Source

Open in PubMed Open full text

Identifiers

PMID: 20082658
DOI: 10.1111/j.1582-4934.2010.01011.x
PMCID: PMC3922377

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20082658-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Early defect of transforming growth factor β1 formation in Huntington's disease.PMID 20082658Read ↗

Reduced hippocampal neurogenesis in R6/2 transgenic Huntington's disease miceSemantic proximity Read ↗

Interleukin-6 deficiency exacerbates Huntington's disease model phenotypes.Semantic proximity Read ↗

Investigating the Gliogenic Genes and Signaling Pathways in the Pathogenesis of Huntington’s Disease: A Systematic ReviewSemantic proximity Read ↗

Chronic Overproduction of Transforming Growth Factor-β1 by Astrocytes Promotes Alzheimer's Disease-Like Microvascular Degeneration in Transgenic MiceSemantic proximity Read ↗

Astrocytes are key but indirect contributors to the development of the symptomatology and pathophysiology of Huntington's disease.Semantic proximity Read ↗

Plasma gangliosides correlate with disease stages and symptom severity in Huntington’s disease carriersSemantic proximity Read ↗

A critical role of astrocyte-mediated nuclear factor-κB-dependent inflammation in Huntington's disease.Semantic proximity Read ↗

Lack of interleukin-1 type 1 receptor enhances the accumulation of mutant huntingtin in the striatum and exacerbates the neurological phenotypes of Huntington's disease mice.Semantic proximity Read ↗

Impaired adult olfactory bulb neurogenesis in the R6/2 mouse model of Huntington's disease.Semantic proximity Read ↗

Mutant huntingtin in glial cells exacerbates neurological symptoms of Huntington disease mice.Semantic proximity Read ↗

Striatal infusion of glial conditioned medium diminishes huntingtin pathology in r6/1 mice.Semantic proximity Read ↗

Expression of brain-derived neurotrophic factor in astrocytes - Beneficial effects of glatiramer acetate in the R6/2 and YAC128 mouse models of Huntington's disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.