Article
Chronic cholesterol administration to the brain supports complete and long-lasting cognitive and motor amelioration in Huntington’s disease
2022-08-26
Abstract excerpt
Evidence that Huntington’s disease (HD) is characterized by impaired cholesterol biosynthesis in the brain has led to strategies to increase its level in the brain of the rapidly progressing R6/2 mouse model, with a positive therapeutic outcome. Here we tested the long-term efficacy of chronic administration of cholesterol to the brain of the slowly progressing zQ175DN knock-in HD mice in preventing (“early treatm...
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Identifiers and source
- Literature Corpus work
- f567ed1a-8009-5feb-94a7-b639e7ee1d1e
- DOI
- 10.1101/2022.08.26.505426