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Article

Rare missense variants in CHRNB3 and CHRNA3 are associated with risk of alcohol and cocaine dependence.

Human molecular genetics - 1 Feb 2014

Haller Gabe, Kapoor Manav, Budde John, Xuei Xiaoling, Edenberg Howard, Nurnberger John, Kramer John, Brooks Andy, Tischfield Jay, Almasy Laura, Agrawal Arpana, Bucholz Kathleen, Rice John, Saccone Nancy, Bierut Laura, Goate Alison

Abstract excerpt

Previous findings have demonstrated that variants in nicotinic receptor genes are associated with nicotine, alcohol and cocaine dependence. Because of the substantial comorbidity, it has often been unclear whether a variant is associated with multiple substances or whether the association is actually with a single substance. To investigate the possible contribution of rare variants to the development of substance...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24057674
DOI: 10.1093/hmg/ddt463
PMCID: PMC3888263

Genes

CHRNB3
CHRNA3
CHRNA5
CHRNA6
CHRNB4

Variants

rs149775276

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Rare missense variants in CHRNB3 and CHRNA3 are associated with risk of alcohol and cocaine dependence.PMID 24057674Read ↗

Multiple distinct CHRNB3-CHRNA6 variants are genetic risk factors for nicotine dependence in African Americans and European Americans.Semantic proximity Read ↗

Rare missense variants in CHRNB4 are associated with reduced risk of nicotine dependence.Semantic proximity Read ↗

Variants near CHRNB3-CHRNA6 are associated with DSM-5 cocaine use disorder: evidence for pleiotropy.Semantic proximity Read ↗

Variation in nicotinic acetylcholine receptor genes is associated with multiple substance dependence phenotypes.Semantic proximity Read ↗

Genetic variation in the CHRNA5 gene affects mRNA levels and is associated with risk for alcohol dependence.Semantic proximity Read ↗

Nicotine dependence and comorbid psychiatric disorders: examination of specific genetic variants in the CHRNA5-A3-B4 nicotinic receptor genes.Semantic proximity Read ↗

The CHRNA5-CHRNA3-CHRNB4 nicotinic receptor subunit gene cluster affects risk for nicotine dependence in African-Americans and in European-Americans.Semantic proximity Read ↗

Investigating CHRNA5, CHRNA3, and CHRNB4 variants in the genetic landscape of substance use disorder in Jordan.Semantic proximity Read ↗

Evidence for Association Between Low Frequency Variants in CHRNA6/CHRNB3 and Antisocial Drug Dependence.Semantic proximity Read ↗

Common single nucleotide variants underlying drug addiction: more than a decade of research.Semantic proximity Read ↗

Genetic association of the CHRNA6 and CHRNB3 genes with tobacco dependence in a nationally representative sample.Semantic proximity Read ↗

SNPs in CHRNA6 and CHRNB3 are associated with alcohol consumption in a nationally representative sample.Semantic proximity Read ↗

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